The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

The advent of the “omics” era in biology research has brought new challenges and requires
the development of novel strategies to answer previously intractable questions. Molecular …

Combinatorial interactions among transcription factors are critical to directing tissue-specific
gene expression. To build a global atlas of these combinations, we have screened for …

Interactions between proteins are essential for their functioning and the biological processes
they control. The elucidation of interaction maps based on yeast studies is a first step toward …

Motivation: High-throughput experiments are being performed at an ever-increasing rate to
systematically elucidate protein–protein interaction (PPI) networks for model organisms …

RNA virus infection is recognized by the RIG-I-like receptors RIG-I and MDA5, which induce
antiviral responses including the production of type I interferons (IFNs) and proinflammatory …

The mitotic checkpoint (or spindle assembly checkpoint) is a fail-safe mechanism to prevent
chromosome missegregation by delaying anaphase onset in the presence of defective …

The mosses and flowering plants diverged> 400 million years ago. The mosses have
haploid-dominant life cycles, whereas the flowering plants are diploid-dominant. The …

The human genome sequence defines our inherent biological potential; the realization of
the biology encoded therein requires knowledge of the function of each gene. Currently, our …

Protein-protein interactions drive biological processes. They are critical for all intra-and
extracellular functions, and the technologies to analyze them are widely applied throughout …