Recent advances in molecular studies on cochlear development and regeneration
Y Sun, Z Liu - Current Opinion in Neurobiology, 2023 - Elsevier
The auditory organ cochlea harbors two types of sound receptors, inner hair cells (IHCs) and
outer hair cells (OHCs), which are innervated by spiral (auditory) ganglion neurons (SGNs) …
outer hair cells (OHCs), which are innervated by spiral (auditory) ganglion neurons (SGNs) …
gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration
To the Editor—Biologists are important stakeholders in genomic data, both as data
generators and as users of genomic data resources. Tools to efficiently visualize and …
generators and as users of genomic data resources. Tools to efficiently visualize and …
Stem cell-based hair cell regeneration and therapy in the inner ear
J Qi, W Huang, Y Lu, X Yang, Y Zhou, T Chen… - Neuroscience …, 2024 - Springer
Hearing loss has become increasingly prevalent and causes considerable disability, thus
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …
gravely burdening the global economy. Irreversible loss of hair cells is a main cause of …
POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism
During embryonic development, hierarchical cascades of transcription factors interact with
lineage-specific chromatin structures to control the sequential steps in the differentiation of …
lineage-specific chromatin structures to control the sequential steps in the differentiation of …
DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration
JD Nguyen, J Llamas, T Shi… - Proceedings of the …, 2023 - National Acad Sciences
Mammalian hair cells do not functionally regenerate in adulthood but can regenerate at
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …
embryonic and neonatal stages in mice by direct transdifferentiation of neighboring …
Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature …
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …
has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression …
SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti
The auditory organ of Corti is comprised of only two major cell types—the mechanosensory
hair cells and their associated supporting cells—both specified from a single pool of …
hair cells and their associated supporting cells—both specified from a single pool of …
Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration
Adult mammalian tissues such as heart, brain, retina, and the sensory structures of the inner
ear do not effectively regenerate, although a latent capacity for regeneration exists at …
ear do not effectively regenerate, although a latent capacity for regeneration exists at …
Expression of Atoh1, Gfi1, and Pou4f3 in the mature cochlea reprograms nonsensory cells into hair cells
Mechanosensory hair cells of the mature mammalian organ of Corti do not regenerate;
consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian …
consequently, loss of hair cells leads to permanent hearing loss. Although nonmammalian …
Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea
S Lee, JJ Song, LA Beyer, DL Swiderski… - Scientific reports, 2020 - nature.com
Mature mammalian cochlear hair cells (HCs) do not spontaneously regenerate once lost,
leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals …
leading to life-long hearing deficits. Attempts to induce HC regeneration in adult mammals …