Patient-derived xenografts undergo mouse-specific tumor evolution
Patient-derived xenografts (PDXs) have become a prominent cancer model system, as they
are presumed to faithfully represent the genomic features of primary tumors. Here we …
are presumed to faithfully represent the genomic features of primary tumors. Here we …
Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases
Metastasis is the primary cause of cancer-related deaths, but the natural history, clonal
evolution and impact of treatment are poorly understood. We analyzed whole-exome …
evolution and impact of treatment are poorly understood. We analyzed whole-exome …
[HTML][HTML] Genomic and clinical significance of multiple primary lung cancers as determined by next-generation sequencing
D Goodwin, V Rathi, M Conron, GM Wright - Journal of Thoracic Oncology, 2021 - Elsevier
Introduction Marked variations in survival rates have brought into question whether standard
clinicopathologic classification should be applied to patients presenting with multiple …
clinicopathologic classification should be applied to patients presenting with multiple …
From Morphology to Molecules: Advances in the Distinction of Multiple Primary Lung Cancers From Intrapulmonary Metastases in Non–Small Cell Lung Cancer
GE Olteanu, I Kern, L Kalson… - Advances in Anatomic …, 2024 - journals.lww.com
The increasing incidence of multiple lung nodules underscores the need for precise
differentiation between multiple primary lung cancers (MPLCs) and intrapulmonary …
differentiation between multiple primary lung cancers (MPLCs) and intrapulmonary …
Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer
Our understanding of genomic heterogeneity in lung cancer is largely based on the analysis
of early-stage surgical specimens. Here we used endoscopic sampling of paired primary …
of early-stage surgical specimens. Here we used endoscopic sampling of paired primary …
Genomic Landscape, Clinical Features and Outcomes of Non-Small Cell Lung Cancer Patients Harboring BRAF Alterations of Distinct Functional Classes
Simple Summary Non-small cell lung cancer (NSCLC) patients harboring BRAF non-V600
alterations constitute a heterogeneous and poorly studied population orphan of targeted …
alterations constitute a heterogeneous and poorly studied population orphan of targeted …
A platform-independent AI tumor lineage and site (ATLAS) classifier
Histopathologic diagnosis and classification of cancer plays a critical role in guiding
treatment. Advances in next-generation sequencing have ushered in new complementary …
treatment. Advances in next-generation sequencing have ushered in new complementary …
[HTML][HTML] Genomic evolution of lung cancer metastasis: current status and perspectives
WF Tang, R Fu, Y Liang, JS Lin, ZB Qiu… - Cancer …, 2021 - ncbi.nlm.nih.gov
Lung cancer is one of the cancers with the highest morbidity and mortality worldwide. Over
the two past decades, although the treatment of non-small cell lung cancer (NSCLC) has …
the two past decades, although the treatment of non-small cell lung cancer (NSCLC) has …
Lung cancer treatment potential and limits associated with the STAT family of transcription factors
P Faida, MKI Attiogbe, U Majeed, J Zhao, L Qu, D Fan - Cellular Signalling, 2023 - Elsevier
Lung cancer is one of the mortal cancers and the leading cause of cancer-related mortality,
with a cancer survival rate of fewer than 5% in develo** nations. This low survival rate can …
with a cancer survival rate of fewer than 5% in develo** nations. This low survival rate can …
Power and pitfalls of computational methods for inferring clone phylogenies and mutation orders from bulk sequencing data
Tumors harbor extensive genetic heterogeneity in the form of distinct clone genotypes that
arise over time and across different tissues and regions in cancer. Many computational …
arise over time and across different tissues and regions in cancer. Many computational …