Inflammation in ALS/FTD pathogenesis
ME McCauley, RH Baloh - Acta neuropathologica, 2019 - Springer
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are
neurodegenerative diseases that overlap in their clinical presentation, pathology and …
neurodegenerative diseases that overlap in their clinical presentation, pathology and …
Emerging mechanisms of molecular pathology in ALS
Amyotrophic lateral sclerosis (ALS) is a devastating degenerative disease characterized by
progressive loss of motor neurons in the motor cortex, brainstem, and spinal cord. Although …
progressive loss of motor neurons in the motor cortex, brainstem, and spinal cord. Although …
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of
amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide …
amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD). The nucleotide …
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
V Swarup, FI Hinz, JE Rexach, K Noguchi… - Nature medicine, 2019 - nature.com
Identifying the mechanisms through which genetic risk causes dementia is an imperative for
new therapeutic development. Here, we apply a multistage, systems biology approach to …
new therapeutic development. Here, we apply a multistage, systems biology approach to …
The clinical spectrum of sporadic and familial forms of frontotemporal dementia
IOC Woollacott, JD Rohrer - Journal of neurochemistry, 2016 - Wiley Online Library
The term frontotemporal dementia (FTD) describes a clinically, genetically and
pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present …
pathologically diverse group of neurodegenerative disorders. Symptoms of FTD can present …
Innate immunity: a common denominator between neurodegenerative and neuropsychiatric diseases
The intricate relationships between innate immunity and brain diseases raise increased
interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders …
interest across the wide spectrum of neurodegenerative and neuropsychiatric disorders …
Genetics of FTLD: overview and what else we can expect from genetic studies
C Pottier, TA Ravenscroft… - Journal of …, 2016 - Wiley Online Library
Frontotemporal lobar degeneration (FTLD) comprises a highly heterogeneous group of
disorders clinically associated with behavioral and personality changes, language …
disorders clinically associated with behavioral and personality changes, language …
Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72
Antibodies are a key resource in biomedical research yet there are no community-accepted
standards to rigorously characterize their quality. Here we develop a procedure to validate …
standards to rigorously characterize their quality. Here we develop a procedure to validate …
TDP-43 real-time quaking induced conversion reaction optimization and detection of seeding activity in CSF of amyotrophic lateral sclerosis and frontotemporal …
The pathological deposition of the transactive response DNA-binding protein of 43 kDa
occurs in the majority (∼ 97%) of amyotrophic lateral sclerosis and in around 45% of …
occurs in the majority (∼ 97%) of amyotrophic lateral sclerosis and in around 45% of …
Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase
Objective To investigate the role of neuroinflammation in asymptomatic and symptomatic
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mutation carriers …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) mutation carriers …