Erythropoiesis is a multi‐step process that involves the differentiation of hematopoietic stem
cells into mature red blood cells (RBCs). This process is regulated by several signaling …

The glycoprotein follicle-stimulating hormone (FSH) acts on gonadal target cells, hence
regulating gametogenesis. The transduction of the hormone-induced signal is mediated by …

Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway regulates cell growth,
proliferation, survival, mobility and invasion. Mitogen-activated protein kinase …

How does the coagulation protease thrombin regulate cellular behaviour? The protease-
activated receptors (PARs) provide one answer. In concert with the coagulation cascade …

PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Publisher Summary This chapter discusses the structure and function of the epidermal
growth factor (EGF) receptor (EGFR), from ligand binding to the initiation of intracellular …

▪ Abstract The phosphoinositide 3-kinase (PI3K) family of enzymes is recruited upon growth
factor receptor activation and produces 3′ phosphoinositide lipids. The lipid products of …

The coagulation cascade and protease‐activated receptors (PARs) together provide an
elegant mechanism that links mechanical information in the form of tissue injury to cellular …

Adult skeletal muscle can regenerate in response to muscle damage. This ability is
conferred by the presence of myogenic stem cells called satellite cells. In response to stimuli …

Phosphoinositide 3-kinases (PI3Ks) generate specific inositol lipids that have been
implicated in the regulation of cell growth, proliferation, survival, differentiation and …