Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for
millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host …

In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

The regulation of proteostasis is fundamental for maintenance of muscle mass and function.
Activation of the TGF-β pathway drives wasting and premature aging by favoring the …

We establish a murine lung-on-chip infection model and use time-lapse imaging to reveal
the dynamics of host-Mycobacterium tuberculosis interactions at an air-liquid interface with a …

Tuberculosis (TB) is one of the leading causes of death due to its being an infectious
disease, caused by the airborne pathogen Mycobacterium tuberculosis (M. tb) …

Humans have been infected with Mycobacterium tuberculosis (Mtb) for thousands of years.
While tuberculosis (TB), one of the deadliest infectious diseases, is caused by uncontrolled …

Science has been taking profit from animal models since the first translational experiments
back in ancient Greece. From there, and across all history, several remarkable findings have …

The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of
Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses …

The Mycobacterium tuberculosis cell envelope has been evolving over time to make the
bacterium transmissible and adaptable to the human host. In this context, the M. tuberculosis …

Even today, tuberculosis in childhood is a disease that is often undiagnosed and
undertreated. In the absence of therapy with antituberculosis drugs, children in the first years …