Therapeutic implications of menin inhibition in acute leukemias
GC Issa, F Ravandi, CD DiNardo, E Jabbour… - Leukemia, 2021 - nature.com
Menin inhibitors are novel targeted agents currently in clinical development for the treatment
of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in …
of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in …
The genetics and mechanisms of T cell acute lymphoblastic leukaemia
L Belver, A Ferrando - Nature Reviews Cancer, 2016 - nature.com
T cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological malignancy
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …
derived from early T cell progenitors. In recent years genomic and transcriptomic studies …
The emerging complexity of gene fusions in cancer
F Mertens, B Johansson, T Fioretos… - Nature Reviews Cancer, 2015 - nature.com
Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in …
DNA sequences between genes. Many such gene fusions are strong driver mutations in …
All roads lead to PP 2A: exploiting the therapeutic potential of this phosphatase
J Sangodkar, CC Farrington, K McClinch… - The FEBS …, 2016 - Wiley Online Library
Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
[HTML][HTML] The molecular basis of T cell acute lymphoblastic leukemia
P Van Vlierberghe, A Ferrando - The Journal of clinical …, 2012 - Am Soc Clin Investig
T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of
hematopoietic progenitors primed toward T cell development, as result of a multistep …
hematopoietic progenitors primed toward T cell development, as result of a multistep …
Protein phosphatase 2A: a target for anticancer therapy
D Perrotti, P Neviani - The lancet oncology, 2013 - thelancet.com
Summary Protein phosphatase 2A (PP2A), one of the main serine–threonine phosphatases
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …
in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven …
Integrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T cell acute lymphoblastic leukemia
I Homminga, R Pieters, AW Langerak, JJ de Rooi… - Cancer cell, 2011 - cell.com
To identify oncogenic pathways in T cell acute lymphoblastic leukemia (T-ALL), we
combined expression profiling of 117 pediatric patient samples and detailed molecular …
combined expression profiling of 117 pediatric patient samples and detailed molecular …
ABT-199 mediated inhibition of BCL-2 as a novel therapeutic strategy in T-cell acute lymphoblastic leukemia
S Peirs, F Matthijssens, S Goossens… - Blood, The Journal …, 2014 - ashpublications.org
T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subtype of acute lymphoblastic
leukemia (ALL) with gradually improved survival through introduction of intensified …
leukemia (ALL) with gradually improved survival through introduction of intensified …
T-cell acute lymphoblastic leukemia: biomarkers and their clinical usefulness
V Bardelli, S Arniani, V Pierini, D Di Giacomo, T Pierini… - Genes, 2021 - mdpi.com
T-cell acute lymphoblastic leukemias (T-ALL) are immature lymphoid tumors localizing in the
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …
bone marrow, mediastinum, central nervous system, and lymphoid organs. They account for …
Histone methyltransferases in cancer
Cancer is perceived as a heterogeneous group of diseases that is characterized by aberrant
patterns of gene expression. In the last decade, an increasing amount of data has pointed to …
patterns of gene expression. In the last decade, an increasing amount of data has pointed to …