Osteogenesis imperfecta is a genetic disorder characterized by low bone mass, decreased
bone strength, increased bone fragility, and shortened stature. Autosomal dominant …

Collagen fibrils are the fundamental structural elements in vertebrate animals and compose
a structural framework that provides mechanical support to load-bearing tissues …

High-speed atomic force microscopy (AFM) enabled the imaging of protein interactions with
millisecond time resolutions (10 fps). However, the acquisition of nanomechanical maps of …

Water constitutes roughly a quarter of the cortical bone by volume yet can greatly influence
mechanical properties and tissue quality. There is a growing appreciation for how water can …

The myotendinous junction is a highly interdigitated interface designed to transfer muscle-
generated force to tendon. Understanding how this interface is formed and organized, as …

Fracture toughness characterizes the ability of a material to maintain a certain level of
strength despite the presence of a macroscopic crack. Understanding this tolerance for …

Membrane separation is a promising approach for the remediation of oil contamination in
water. High-flux separation of membrane relies on the rational design of ultrathin active layer …

Bladder mechanical properties are critical for organ function and tissue homeostasis.
Therefore, alterations of tissue mechanics are linked to disease onset and progression. This …

Water is known to play an important role in collagen self-assembly, but it is still largely
unclear how water–collagen interactions influence the assembly process and determine the …

Collagen is the basic protein of animal tissues and has a complex hierarchical structure. It
plays a crucial role in maintaining the mechanical and structural stability of biological …