Molecular biology of KSHV lytic reactivation
Kaposi's sarcoma-associated herpesvirus (KSHV) primarily persists as a latent episome in
infected cells. During latent infection, only a limited number of viral genes are expressed that …
infected cells. During latent infection, only a limited number of viral genes are expressed that …
Primary mediastinal nodal and extranodal non-Hodgkin lymphomas: current concepts, historical evolution, and useful diagnostic approach: part 1
S Piña-Oviedo, CA Moran - Advances in anatomic pathology, 2019 - journals.lww.com
Primary mediastinal non-Hodgkin lymphomas (PM-NHLs) represent~ 5% of all NHLs and
comprise lymphomas of B-cell and T-cell origin. PM-NHLs are defined as involvement of …
comprise lymphomas of B-cell and T-cell origin. PM-NHLs are defined as involvement of …
IRF4 and IRF8: Governing the virtues of B Lymphocytes
V Shukla, R Lu - Frontiers in biology, 2014 - Springer
Abstract Interferon regulatory factor 4 (IRF4) and IRF8 are critical regulators of immune
system development and function. In B lymphocytes, IRF4 and IRF8 have been shown to …
system development and function. In B lymphocytes, IRF4 and IRF8 have been shown to …
The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved RNA decay
mechanism that has emerged as a potent cell-intrinsic restriction mechanism of retroviruses …
mechanism that has emerged as a potent cell-intrinsic restriction mechanism of retroviruses …
Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical …
Interferon regulatory factor 8 (IRF8), also known as interferon consensus sequence-binding
protein (ICSBP), is a transcription factor of the IRF family. IRF8 plays a key role in normal B …
protein (ICSBP), is a transcription factor of the IRF family. IRF8 plays a key role in normal B …
Global epigenomic analysis of KSHV-infected primary effusion lymphoma identifies functional MYC superenhancers and enhancer RNAs
Enhancers play indispensable roles in cell proliferation and survival through
spatiotemporally regulating gene transcription. Active enhancers and superenhancers often …
spatiotemporally regulating gene transcription. Active enhancers and superenhancers often …
Diverse mechanisms evolved by DNA viruses to inhibit early host defenses
In mammalian cells, early defenses against infection by pathogens are mounted through a
complex network of signaling pathways shepherded by immune-modulatory pattern …
complex network of signaling pathways shepherded by immune-modulatory pattern …
Innate immune responses to herpesvirus infection
CM O'Connor, GC Sen - Cells, 2021 - mdpi.com
Infection of a host cell by an invading viral pathogen triggers a multifaceted antiviral
response. One of the most potent defense mechanisms host cells possess is the interferon …
response. One of the most potent defense mechanisms host cells possess is the interferon …
USP7 manipulation by viral proteins
Abstract Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays
critical roles in the regulation of many cellular processes including epigenetics, tumour …
critical roles in the regulation of many cellular processes including epigenetics, tumour …
Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection
Polyamines are critical metabolites involved in various cellular processes and often
dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined …
dysregulated in cancers. Kaposi's sarcoma-associated Herpesvirus (KSHV), a defined …