Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Hepatocellular carcinoma (HCC) is an aggressive disease with a poor clinical outcome. The
cancer stem cell (CSC) model states that tumour growth is powered by a subset of tumour …

The last 3 years have seen the emergence of promising targeted therapies for the treatment
of hepatocellular carcinoma (HCC). Sorafenib has been the mainstay of treatment for a …

Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, typically
develops on the background of chronic liver disease and is an aggressive disease with …

Interaction between tumor cells and immune cells in the tumor microenvironment is
important in cancer development. Immune cells interact with the tumor cells to shape this …

Intratumor heterogeneity may result from the evolution of tumor cells and their continuous
interactions with the tumor microenvironment which collectively drives tumorigenesis …

One of the most fundamental questions in biology is what types of cells form different tissues
and organs in a functionally coordinated fashion. Larger-scale single-cell sequencing and …

Single-cell sequencing-based methods for profiling gene transcript levels have revealed
substantial heterogeneity in expression levels among morphologically indistinguishable …

Heterogeneity is the major challenge for cancer prevention and therapy. Here, we first
constructed high-resolution spatial transcriptomes of primary liver cancers (PLCs) containing …