N-Heterocyclic carbenes, despite being isolated and characterized three decades ago, still
capture scientists' interest as versatile, modular and strongly coordinating moieties. In the …

In nature, a number of enzymes use thiamine diphosphate as a coenzyme to catalyze the
pyruvate decarboxylation. The resultant enamine, a so-called “Breslow intermediate,” is …

Radical/radical cross-coupling reactions represent an efficient and straightforward approach
for the construction of chemical bonds and accordingly have drawn increasing attention over …

As one of the most important key intermediates, NHC-bound acylazolium-based ionic
transformations have been intensively explored in the past two decades. With the …

The 2, 3-dihydrobenzofuran scaffold is widely found in natural products and biologically
active compounds. Herein, dearomatizing 2, 3-fluoroaroylation of benzofurans with aroyl …

N-Heterocyclic carbene (NHC) organocatalysis to promote so-called umpolung reactions
has emerged as a powerful tool for modern organic synthesis. NHC-bound nucleophiles …

N-Heterocyclic carbene (NHC) catalysis has emerged as a versatile tool in modern synthetic
chemistry. Further increasing the complexity, several processes have been introduced that …

N‐Heterocyclic carbene (NHC) organocatalysis has been developed as an important
approach in modern organic synthesis. Versatile activation modes within NHC …

Methods that enable site selective acylation of sp3 CH bonds in complex organic molecules
are not well explored, particularly if compared with analogous transformations of aromatic …

We found that N-heterocyclic carbene catalysis promoted the unprecedented
decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid …