Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein–Barr virus and the gut–brain axis

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …

Overview of the potential use of fluvoxamine for COVID-19 and long COVID

K Hashimoto - Discover Mental Health, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) has presented a serious worldwide threat to
public health since its emergence in late 2019. From a safety point of view, drug repurposing …

Depression and anxiety before and at the beginning of the COVID-19 pandemic and incident persistent symptoms: a prospective population-based cohort study

J Matta, O Robineau, E Wiernik, F Carrat, G Severi… - Molecular …, 2023 - nature.com
Many patients affected by COVID-19 suffer from debilitating persistent symptoms whose risk
factors remained poorly understood. This prospective study examined the association of …

[HTML][HTML] Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a …

DL Wannigama, C Hurst, P Phattharapornjaroen… - …, 2024 - thelancet.com
Background Repurposed drugs with host-directed antiviral and immunomodulatory
properties have shown promise in the treatment of COVID-19, but few trials have studied …

The relationship between COVID-19 and the development of depression: implications on mental health

PA Shetty, L Ayari, J Madry, C Betts… - Neuroscience …, 2023 - journals.sagepub.com
Initially, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus
responsible for coronavirus disease-2019 (COVID-19), was predominantly considered to …

Association of severe mental illness and septic shock case fatality rate in patients admitted to the intensive care unit: A national population-based cohort study

I Lakbar, M Leone, V Pauly, V Orleans… - PLoS …, 2023 - journals.plos.org
Background Patients with severe mental illness (SMI)(ie, schizophrenia, bipolar disorder, or
major depressive disorder) have been reported to have excess mortality rates from infection …

A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID …

MI Prasanth, DL Wannigama, AM Reiersen… - Scientific reports, 2024 - nature.com
Abstract There have been 774,075,242 cases of COVID-19 and 7,012,986 deaths worldwide
as of January 2024. In the early stages of the pandemic, there was an urgent need to reduce …

SSRI use during acute COVID-19 infection associated with lower risk of long COVID among patients with depression

Z Butzin-Dozier, Y Ji, S Deshpande, E Hurwitz, J Coyle… - medRxiv, 2024 - medrxiv.org
Background Long COVID, also known as post-acute sequelae of COVID-19 (PASC), is a
poorly understood condition with symptoms across a range of biological domains that often …

[HTML][HTML] Fluvoxamine: First comprehensive insights into its molecular characteristics and inclusion complexation with β-cyclodextrin

T Aree - Journal of Pharmaceutical Analysis, 2025 - Elsevier
Fluvoxamine (FXM) is a well-known selective serotonin reuptake inhibitor (SSRI) for treating
depression and has recently been repurposed for efficacious treatment of coronavirus …

Clinically Evaluated COVID-19 Drugs with Therapeutic Potential for Biological Warfare Agents

ID Dechtman, R Ankory, K Sokolinsky, E Krasner… - Microorganisms, 2023 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak resulted in
hundreds of millions of coronavirus cases, as well as millions of deaths worldwide …