Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …

More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …

Background Anti-cytokine therapies such as adalimumab, tocilizumab, and the small
molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent …

The growth hormone receptor (GHR), although most well known for regulating growth, has
many other important biological functions including regulating metabolism and controlling …

The JAK (Janus kinase) family members serve essential roles as the intracellular signalling
effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine …

Since its discovery two decades ago, the activation of the Janus kinase/signal transducers
and activators of transcription (JAK/STAT) pathway by numerous cytokines and growth …

A significant number of drugs and drug candidates in clinical development are halogenated
structures. For a long time, insertion of halogen atoms on hit or lead compounds was …

Background The V617F mutation, which causes the substitution of phenylalanine for valine
at position 617 of the Janus kinase (JAK) 2 gene (JAK2), is often present in patients with …

Introduction Class I cytokines regulate key processes such as growth, lactation,
hematopoiesis, and immune function and contribute to oncogenesis. Although the …

During SARS-CoV-2 infection, the innate immune response can be inhibited or delayed, and
the subsequent persistent viral replication can induce emergency signals that may culminate …