Mitochondrial signal transduction
The analogy of mitochondria as powerhouses has expired. Mitochondria are living, dynamic,
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …
maternally inherited, energy-transforming, biosynthetic, and signaling organelles that …
Oxidative stress in human pathology and aging: molecular mechanisms and perspectives
Reactive oxygen and nitrogen species (RONS) are generated through various endogenous
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
and exogenous processes; however, they are neutralized by enzymatic and non-enzymatic …
Calcium signaling and reactive oxygen species in mitochondria
In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …
[HTML][HTML] Activity-driven local ATP synthesis is required for synaptic function
Cognitive function is tightly related to metabolic state, but the locus of this control is not well
understood. Synapses are thought to present large ATP demands; however, it is unclear …
understood. Synapses are thought to present large ATP demands; however, it is unclear …
Mitochondrial disorders as windows into an ancient organelle
Much of our current knowledge about mitochondria has come from studying patients who
have respiratory chain disorders. These disorders comprise a large collection of individually …
have respiratory chain disorders. These disorders comprise a large collection of individually …
The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter
X Pan, J Liu, T Nguyen, C Liu, J Sun, Y Teng… - Nature cell …, 2013 - nature.com
Mitochondrial calcium has been postulated to regulate a wide range of processes from
bioenergetics to cell death. Here, we characterize a mouse model that lacks expression of …
bioenergetics to cell death. Here, we characterize a mouse model that lacks expression of …
Mechanisms of vitamin D on skeletal muscle function: oxidative stress, energy metabolism and anabolic state
KP Dzik, JJ Kaczor - European journal of applied physiology, 2019 - Springer
Purpose This review provides a current perspective on the mechanism of vitamin D on
skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and …
skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and …
[HTML][HTML] Metabolic cycles and signals for insulin secretion
In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …
Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling
R Filadi, E Greotti, G Turacchio… - Proceedings of the …, 2015 - National Acad Sciences
The organization and mutual interactions between endoplasmic reticulum (ER) and
mitochondria modulate key aspects of cell pathophysiology. Several proteins have been …
mitochondria modulate key aspects of cell pathophysiology. Several proteins have been …
The mitochondrial calcium uniporter matches energetic supply with cardiac workload during stress and modulates permeability transition
Cardiac contractility is mediated by a variable flux in intracellular calcium (Ca 2+), thought to
be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to …
be integrated into mitochondria via the mitochondrial calcium uniporter (MCU) channel to …