Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

Wnt/β-catenin-mediated signaling is a key pathway regulating tissue growth and
development, and tumorigenesis, and has received increasing attention in recent years. In …

Introduction: Colorectal cancer (CRC) frequently harbors KRAS mutations that result in
chemoresistance and metastasis. MicroRNAs (miRNAs) are usually dysregulated and play …

Colorectal cancer (CRC) is the third most prevalent cancer type and accounts for nearly one
million deaths worldwide. The CRC mRNA gene expression datasets from TCGA and GEO …

Abstract Introduction: Serine hydroxymethyltransferase 2 (SHMT2) plays a critical role in
serine-glycine metabolism to drive cancer cell proliferation. However, the nonmetabolic …

Colorectal cancer (CRC) is a common cause of cancer-related deaths worldwide. The CRC
mRNA gene expression dataset containing 644 CRC tumor and 51 normal samples from the …

Wnt signaling plays crucial roles in development and tissue homeostasis, and its
dysregulation leads to various diseases, notably cancer. Wnt/β-catenin signaling is initiated …

Targeting specific molecular drivers of tumor growth is a key approach in cancer therapy.
Among these targets, the low-density lipoprotein receptor-related protein 6 (LRP6), a vital …

Immunoglobulin (Ig) VSTM2A (V-set and transmembrane domain containing 2A) is a top-
ranked secretory protein frequently silenced during colorectal carcinogenesis; however, its …