The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

For more than 25 years, MDM2 and its homolog MDMX (also known as MDM4) have been
shown to exert oncogenic activity. These two proteins are best understood as negative …

Inactivation of the tumor suppressor p53 and/or overexpression of the oncogene MDM2
frequently occur in human cancers, and are associated with poor prognosis, advanced forms …

Organ fibrosis represents a dysregulated, maladaptive wound repair response that results in
progressive disruption of normal tissue architecture leading to detrimental deterioration in …

Thyroid cancers are common endocrine malignancies that comprise tumors with different
clinical and histological features. Indeed, papillary and follicular thyroid cancers are slow …

Alternative splicing of pre‐messenger RNA (mRNA) is a fundamental mechanism by which a
gene can give rise to multiple distinct mRNA transcripts, yielding protein isoforms with …

The oncogene MDMX, also known as MDM4 is a critical negative regulator of the tumor
suppressor p53 and has been implicated in the initiation and progression of human cancers …

The oncogenic MDM4, initially named MDMX, has been identified as a p53-interacting
protein and a key upstream negative regulator of the tumor suppressor p53. Accumulating …

Conventional high-grade osteosarcoma is the most common primary bone malignancy.
Although altered expression of the p53 inhibitor HDMX (Mdmx/Mdm4) is associated with …

The P53 pathway is the most important cellular pathway to maintain genomic and cellular
integrity, both in embryonic and non-embryonic cells. Stress signals induce its activation …