Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and
chronic inflammation, involving multiple cellular dysfunctions and tissue lesions. The non …

With the increasing and aging of global population, there is a dramatic rise in the demand for
implants or substitutes to rehabilitate bone-related disorders which can considerably …

Abstract 3D‐printed polycaprolactone (PCL) scaffolds have been extensively studied for
application in bone tissue engineering. However, PCL‐based scaffolds with enhanced …

Rapid and effective repair of injured or diseased bone defects remains a major challenge
due to shortages of implants. Smart hydrogels that respond to internal and external stimuli to …

As the global population ages, bone‐related diseases have increasingly become a major
social problem threatening human health. Exosomes, as natural cell products, have been …

Nanomedicines with controlled drug release have received increasing attention as an
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …

Highlights•We categorize the challenges and corresponding solutions for nano-drug
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …

Bone diseases including osteoarthritis, osteoporosis, and bone tumors are becoming severe
threats to public health. Bone-targeted biomaterials-based strategies could improve …

Osteoporosis (OP) is a systemic bone disease characterized by reduction of bone mass and
destruction of structure, which can easily lead to fragility fractures. Over the past decade, an …

Targeted delivery by either systemic or local targeting of therapeutics to the bone is an
attractive treatment for various bone metabolism diseases such as osteoporosis …