Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Abstract MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif)
ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The
increase in the number of sublining macrophages in the synovium is an early hallmark of …

The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Macrophages are central to the pathophysiology of rheumatoid arthritis (RA). They constitute
the main source of pro-inflammatory cytokines and chemokines such as TNF and IL-1β, they …

Purpose: To determine the role of the CCL2/CCR2 axis and inflammatory monocytes
(CCR2+/CD14+) as immunotherapeutic targets in the treatment of pancreatic cancer …

▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …

Purpose: Adoptive T-cell immunotherapy with tumor infiltrating lymphocytes or genetically-
modified T cells has yielded dramatic results in some cancers. However, T cells need to …

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation
in joints, associated with synovial hyperplasia and with bone and cartilage destruction …