Signaling pathways in cancer metabolism: mechanisms and therapeutic targets

M You, Z **e, N Zhang, Y Zhang, D **ao, S Liu… - Signal transduction and …, 2023 - nature.com
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can
be sensed by specific sensors, then trigger a series of signal transduction pathways and …

Genetic and biological drivers of prostate cancer disparities in Black men

J Gong, DM Kim, MR Freeman, H Kim, L Ellis… - Nature Reviews …, 2024 - nature.com
Black men with prostate cancer have historically had worse outcomes than white men with
prostate cancer. The causes of this disparity in outcomes are multi-factorial, but a potential …

Nomogram predicts risk and prognostic factors for bone metastasis of pancreatic cancer: a population-based analysis

W Zhang, L Ji, X Wang, S Zhu, J Luo, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Background The overall survival (OS) of pancreatic cancer (PC) patients with bone
metastasis (BM) is extremely low, and it is pretty hard to treat bone metastasis. However …

A novel ten-gene signature predicting prognosis in hepatocellular carcinoma

T Zhou, Z Cai, N Ma, W **e, C Gao, M Huang… - Frontiers in cell and …, 2020 - frontiersin.org
Hepatocellular carcinoma (HCC) has a dismal long-term outcome. We aimed to construct a
multi-gene model for prognosis prediction to inform HCC management. The cancer-specific …

Synergistic Regulation of Targeted Organelles in Tumor Cells to Promote Photothermal‐Immunotherapy Using Intelligent Core‐Satellite‐Like Nanoparticles for …

X Chang, X Tang, W Tang, L Weng, T Liu, Z Zhu, J Liu… - Small, 2024 - Wiley Online Library
The normal operation of organelles is critical for tumor growth and metastasis. Herein, an
intelligent nanoplatform (BMAEF) is fabricated to perform on‐demand destruction of …

[HTML][HTML] Cellular and molecular progression of prostate cancer: models for basic and preclinical research

S Saranyutanon, SK Deshmukh, S Dasgupta, S Pai… - Cancers, 2020 - mdpi.com
Simple Summary The molecular progression of prostate cancer is complex and elusive.
Biological research relies heavily on in vitro and in vivo models that can be used to examine …

Circular RNA circ-0016068 promotes the growth, migration, and invasion of prostate cancer cells by regulating the miR-330-3p/BMI-1 axis as a competing …

Q Li, W Wang, M Zhang, W Sun, W Shi… - Frontiers in Cell and …, 2020 - frontiersin.org
Prostate cancer is a common neoplasm worldwide, and the sixth most common cause of
cancer-related mortality. Biomarkers for earlier diagnosis and improved treatment …

A novel BMI-1 inhibitor QW24 for the treatment of stem-like colorectal cancer

J Wang, Y **ng, Y Wang, Y He, L Wang, S Peng… - Journal of Experimental …, 2019 - Springer
Background Cancer-initiating cell (CIC), a functionally homogeneous stem-like cell
population, is resonsible for driving the tumor maintenance and metastasis, and is a source …

H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death

Y Zhang, J Shi, X Liu, Z **ao, G Lei, H Lee… - Cancer …, 2020 - aacrjournals.org
Epigenetic regulation of gene transcription has been shown to coordinate with nutrient
availability, yet the mechanisms underlying this coordination remain incompletely …

LncRNA SNHG3 enhances BMI1 mRNA stability by binding and regulating c‐MYC: Implications for the carcinogenic role of SNHG3 in bladder cancer

J **e, J Ni, H Shi, K Wang, X Ma, W Li… - Cancer Medicine, 2023 - Wiley Online Library
The transformation of nonmuscle‐invasive bladder cancer (BLCa) to muscle‐invasive type
and distant metastasis are the two major threats to patients after surgery. Thus, it is important …