The diverse roles of DNA methylation in mammalian development and disease
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …
Clonal hematopoiesis: mechanisms driving dominance of stem cell clones
The discovery of clonal hematopoiesis (CH) in older individuals has changed the way
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …
hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem …
Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes
The TET enzymes are members of the 2-oxoglutarate-dependent dioxygenase family and
comprise three isoenzymes in humans: TETs 1–3. These TETs convert 5-methylcytosine to 5 …
comprise three isoenzymes in humans: TETs 1–3. These TETs convert 5-methylcytosine to 5 …
Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells
Mutations in the epigenetic modifiers DNMT3A and TET2 non-randomly co-occur in
lymphoma and leukemia despite their epistasis in the methylation–hydroxymethylation …
lymphoma and leukemia despite their epistasis in the methylation–hydroxymethylation …
Connections between TET proteins and aberrant DNA modification in cancer
DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer,
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …
Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts
Even though pancreatic ductal adenocarcinoma (PDAC) is associated with fibrotic stroma,
the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are …
the molecular pathways regulating the formation of cancer associated fibroblasts (CAFs) are …
TET family dioxygenases and DNA demethylation in stem cells and cancers
The methylation of cytosine and subsequent oxidation constitutes a fundamental epigenetic
modification in mammalian genomes, and its abnormalities are intimately coupled to various …
modification in mammalian genomes, and its abnormalities are intimately coupled to various …
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia
AH Shih, Y Jiang, C Meydan, K Shank, S Pandey… - Cancer cell, 2015 - cell.com
Specific combinations of acute myeloid leukemia (AML) disease alleles, including FLT3 and
TET2 mutations, confer distinct biologic features and adverse outcome. We generated mice …
TET2 mutations, confer distinct biologic features and adverse outcome. We generated mice …