Bioinformatic analysis of a PLP-dependent enzyme superfamily suitable for biocatalytic applications
F Steffen-Munsberg, C Vickers, H Kohls, H Land… - Biotechnology …, 2015 - Elsevier
In this review we analyse structure/sequence–function relationships for the superfamily of
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …
PLP-dependent enzymes with special emphasis on class III transaminases. Amine …
Advances in riboswitch‐based biosensor as food samples detection tool
Food safety has always been a hot issue of social concern, and biosensing has been widely
used in the field of food safety detection. Compared with traditional aptamer‐based …
used in the field of food safety detection. Compared with traditional aptamer‐based …
Biosynthetic Origin of the octose core and its mechanism of assembly during apramycin biosynthesis
Apramycin is an aminoglycoside antibiotic isolated from Streptoalloteichus tenebrarius and
S. hindustanus that has found clinical use in veterinary medicine. The apramycin structure is …
S. hindustanus that has found clinical use in veterinary medicine. The apramycin structure is …
Biosynthetic genes for aminoglycoside antibiotics
Biosynthetic studies of aminoglycoside antibiotics have progressed remarkably during the
last decade. Many biosynthetic gene clusters for aminoglycoside antibiotics including …
last decade. Many biosynthetic gene clusters for aminoglycoside antibiotics including …
Delineating the biosynthesis of gentamicin X2, the common precursor of the gentamicin C antibiotic complex
Gentamicin C complex is a mixture of aminoglycoside antibiotics used worldwide to treat
severe Gram-negative bacterial infections. Despite its clinical importance, the enzymology of …
severe Gram-negative bacterial infections. Despite its clinical importance, the enzymology of …
Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation
JW Park, SR Park, KK Nepal, AR Han, YH Ban… - Nature chemical …, 2011 - nature.com
Kanamycin is one of the most widely used antibiotics, yet its biosynthetic pathway remains
unclear. Current proposals suggest that the kanamycin biosynthetic products are linearly …
unclear. Current proposals suggest that the kanamycin biosynthetic products are linearly …
Characterization of a Radical S-Adenosyl-l-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis
F Kudo, S Hoshi, T Kawashima… - Journal of the …, 2014 - ACS Publications
The last step of neomycin biosynthesis is the epimerization at C-5‴ of neomycin C to give
neomycin B. A candidate enzyme responsible for the epimerization was a putative radical S …
neomycin B. A candidate enzyme responsible for the epimerization was a putative radical S …
2-Deoxystreptamine-containing aminoglycoside antibiotics: recent advances in the characterization and manipulation of their biosynthetic pathways
Covering: 2007 to September 2012The 2-deoxystreptamine-containing aminoglycosides,
such as neomycin, kanamycin and gentamicin, are an important class of antibiotics. A …
such as neomycin, kanamycin and gentamicin, are an important class of antibiotics. A …
Aminoglycoside antibiotics: new insights into the biosynthetic machinery of old drugs
Deoxystreptamine (2DOS) is the unique chemically stable aminocyclitol scaffold of clinically
important aminoglycoside antibiotics such as neomycin, kanamycin, and gentamicin, which …
important aminoglycoside antibiotics such as neomycin, kanamycin, and gentamicin, which …
The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars
Carbohydrates serve many structural and functional roles in biology. While the majority of
monosaccharides are characterized by the chemical composition (CH2O) n, modifications …
monosaccharides are characterized by the chemical composition (CH2O) n, modifications …