Abstract The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able
to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells …

Allogeneic hematopoietic stem cell transplantation (alloSCT) is an important curative
therapy for high-risk hematological malignancies, but the development of severe and/or …

Allogeneic stem cell transplantation is a cornerstone of curative therapy for high-risk and/or
advanced hematological malignancies but remains limited by graft-versus-host disease …

We determined the efficacy of tocilizumab (TCZ) in preventing grade 2-4 acute graft-versus-
host disease (aGVHD) in patients with acute leukemia or myelodysplasia undergoing …

Background: We examined components of systemic and intestinal renin-angiotensin system
on gut barrier permeability, glucose homeostasis, systemic inflammation, and progression of …

Mature T helper (Th) effector cells originate following antigen recognition by naive T
precursors. The maturation process is accompanied by the acquisition of specific effector …

Graft-versus-host disease (GVHD) is the major cause of nonrelapse morbidity and mortality
after allogeneic stem cell transplantation (allo-SCT). Prevention and treatment of GVHD …

Autophagy is an intracellular survival process that has established roles in the long-term
survival and function of hematopoietic stem cells (HSC). We investigated the contribution of …

Calcineurin inhibitors (CNIs) constitute the backbone of modern acute graft-versus-host
disease (aGVHD) prophylaxis regimens but have limited efficacy in the prevention and …

Graft‐versus‐host disease (GVHD) is a life‐threatening complication following donor
hematopoietic stem cell transplantation, where donor T cells damage host tissues. This …