The genetic basis of long QT and short QT syndromes: a mutation update

PL Hedley, P Jørgensen, S Schlamowitz… - Human …, 2009 - Wiley Online Library
Long QT and short QT syndromes (LQTS and SQTS) are cardiac repolarization
abnormalities that are characterized by length perturbations of the QT interval as measured …

Assessing QT interval prolongation and its associated risks with antipsychotics

J Nielsen, C Graff, JK Kanters, E Toft, D Taylor… - CNS drugs, 2011 - Springer
Several antipsychotics are associated with the ventricular tachycardia torsade de pointes
(TdP), which may lead to sudden cardiac death (SCD), because of their inhibition of the …

Differentiating drug‐induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil

L Johannesen, J Vicente, JW Mason… - Clinical …, 2014 - Wiley Online Library
Block of the hERG potassium channel and prolongation of the QT interval are predictors of
drug‐induced torsade de pointes. However, drugs that block the hERG potassium channel …

Association between Tp‐e/QT ratio and prognosis in patients undergoing primary percutaneous coronary intervention for ST‐segment elevation myocardial infarction

X Zhao, Z **e, Y Chu, L Yang, W Xu, X Yang… - Clinical …, 2012 - Wiley Online Library
Abstract Background: Both the Tpeak‐Tend interval (Tp‐e) and the Tp‐e/QT ratio have been
linked to increased risk for arrhythmia. Patient Tp‐e/QT ratios were investigated prior to …

The prognostic value of the Tpeak-Tend interval in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

C Haarmark, PR Hansen, E Vedel-Larsen… - Journal of …, 2009 - Elsevier
INTRODUCTION: The Tpeak-Tend interval (TpTe) has been linked to increased arrhythmic
risk. TpTe was investigated before and after primary percutaneous coronary intervention …

Evaluation of index of cardio‐electrophysiological balance (iCEB) as a new biomarker for the identification of patients at increased arrhythmic risk

T Robyns, HR Lu, DJ Gallacher… - Annals of …, 2016 - Wiley Online Library
Background Recently a new risk marker for drug‐induced arrhythmias called index of cardio‐
electrophysiological balance (iCEB), measured as QT interval divided by QRS duration, was …

KCNQ1 long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia

SS Torekov, E Iepsen, M Christiansen, A Linneberg… - Diabetes, 2014 - diabetesjournals.org
Patients with loss-of-function mutations in KCNQ1 have KCNQ1 long QT syndrome (LQTS).
KCNQ1 encodes a voltage-gated K+ channel located in both cardiomyocytes and pancreatic …

Reference values of electrocardiogram repolarization variables in a healthy population

C Haarmark, C Graff, MP Andersen, T Hardahl… - Journal of …, 2010 - Elsevier
INTRODUCTION: Reference values for T-wave morphology analysis and evaluation of the
relationship with age, sex, and heart rate are lacking in the literature. In this study, we …

Cardiovascular safety of antipsychotics: a clinical overview

C Polcwiartek, K Kragholm, O Schjerning… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Although antipsychotics have been associated with sudden cardiac death
(SCD), they still remain a cornerstone in the treatment of psychiatric patients. Most …

Electrocardiographic predictors of cardiovascular mortality

I Mozos, A Caraba - Disease markers, 2015 - Wiley Online Library
Cardiovascular diseases are the main causes of mortality. Sudden cardiac death may also
appear in athletes, due to underlying congenital or inherited cardiac abnormalities. The …