Abstract Background Drug target Mendelian randomization describes the use of genetic
variants as instrumental variables for studying the effects of pharmacological agents. The …

Kidney failure, the decrease of kidney function below a threshold necessary to support life, is
a major cause of morbidity and mortality. We performed a genome-wide association study …

Diabetic kidney disease (DKD) is a leading diabetic complication causing significant
mortality among people around the globe. People with poor glycemic control accompanied …

Epigenetic markers are potential biomarkers for diabetes and related complications. Using a
prospective cohort from the Hong Kong Diabetes Register, we perform two independent …

Background The pathophysiological causes of kidney disease are not fully understood. Here
we show that the integration of genome-wide genetic, transcriptomic, and proteomic …

Abstract The Rotterdam Study is a population-based cohort study, started in 1990 in the
district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the …

Chronic kidney disease (CKD) impacts about 1 in 7 adults in the United States, but African
Americans (AAs) carry a disproportionately higher burden of disease. Epigenetic …

Diabetic nephropathy (DN) is a polygenic disorder with few risk variants showing robust
replication in large-scale genome-wide association studies. To understand the role of DNA …

Epigenetic changes may fill a critical gap in our understanding of kidney disease
development, as they not only reflect metabolic changes but are also preserved and …

Identifying genomic regions pertinent to complex traits is a common goal of genome-wide
and epigenome-wide association studies (GWAS and EWAS). GWAS identify causal genetic …