▪ Abstract Hemagglutinin (HA) is the receptor-binding and membrane fusion glycoprotein of
influenza virus and the target for infectivity-neutralizing antibodies. The structures of three …

The docking field has come of age. The time is ripe to present the principles of docking,
reviewing the current state of the field. Two reasons are largely responsible for the maturity …

Abstract The Protein Data Bank (PDB; http://www. rcsb. org/pdb/) is the single worldwide
archive of structural data of biological macromolecules. This paper describes the goals of …

The MDM2 oncoprotein is a cellular inhibitor of the p53 tumor suppressor in that it can bind
the transactivation domain of p53 and downregulate its ability to activate transcription. In …

Histone acetylation is important in chromatin remodelling and gene activation,,,. Nearly all
known histone-acetyltransferase (HAT)-associated transcriptional co-activators contain …

The crystal structure of the 20S proteasome from the yeast Saccharomyces cerevisiae
shows that its 28 protein subunits are arranged as an (α1... α7, β1... β7) 2 complex in four …

The crystallographically determined structure of a soluble fragment from the major envelope
protein of a flavivirus reveals an unusual architecture. The flat, elongated dimer extends in a …

A high-resolution model of the microtubule has been obtained by docking the crystal
structure of tubulin into a 20 Å map of the microtubule. The excellent fit indicates the …

Norwalk virus, a noncultivatable human calicivirus, is the major cause of epidemic
gastroenteritis in humans. The first x-ray structure of a calicivirus capsid, which consists of …

Tetratrico peptide repeat (TPR) proteins have several interesting properties, including their
folding characteristics, modular architecture and range of binding specificities. In the past …