Traditional biochemical methods for enzyme detection are mainly based on antibody-based
immunoassays, which lack the ability to monitor the spatiotemporal distribution and, in …

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an important repair enzyme that removes
various covalent adducts from the 3′ end of DNA. Particularly, covalent complexes of …

DExD/H-box RNA helicases (DDX/DHX) are encoded by a large paralogous gene family; in
a subset of these human helicase genes, pathogenic variation causes neurodevelopmental …

Background Camptothecin (CPT) and its derivatives are currently used as second-or third-
line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert …

A number of derivatives of 7-hydroxycoumarins containing aromatic or monoterpene
substituents at hydroxy-group were synthesized based on a hit compound from a virtual …

Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the
effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by …

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends
topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the …

The ability of a number of nitrogen-containing compounds that simultaneously carry the
adamantane and monoterpene moieties to inhibit Tdp1, an important enzyme of the DNA …

Featured Application Inhibition of Tdp1 has the potential to increase the potency of the
anticancer drugs topotecan and irinotecan, topoisomerase 1 poisons. Furthermore, Tdp1 …

Rhabdomyosarcoma is the most common soft tissue sarcoma in children. Metastatic
rhabdomyosarcoma in children has a 5-year event-free survival rate of< 30%, and a recent …