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Rational design of immunomodulatory hydrogels for chronic wound healing
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …
Smart and bioinspired systems for overcoming biological barriers and enhancing disease theranostics
Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …
Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis
X Wang, G Luo, K Zhang, J Cao, C Huang, T Jiang… - Cancer research, 2018 - AACR
Exosomes are emerging as important mediators of the cross-talk between tumor cells and
the microenvironment. However, the mechanisms by which exosomes modulate tumor …
the microenvironment. However, the mechanisms by which exosomes modulate tumor …
Nanoparticles targeting macrophages as potential clinical therapeutic agents against cancer and inflammation
G Hu, M Guo, J Xu, F Wu, J Fan, Q Huang… - Frontiers in …, 2019 - frontiersin.org
With the development of nanotechnology, significant progress has been made in the design,
and manufacture of nanoparticles (NPs) for use in clinical treatments. Recent increases in …
and manufacture of nanoparticles (NPs) for use in clinical treatments. Recent increases in …
Control of macrophage metabolism and activation by mTOR and Akt signaling
AJ Covarrubias, HI Aksoylar, T Horng - Seminars in immunology, 2015 - Elsevier
Macrophages are pleiotropic cells that assume a variety of functions depending on their
tissue of residence and tissue state. They maintain homeostasis as well as coordinate …
tissue of residence and tissue state. They maintain homeostasis as well as coordinate …
Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity
N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2024 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …
Extracellular vesicles for improved tumor accumulation and penetration
N Bie, T Yong, Z Wei, L Gan, X Yang - Advanced drug delivery reviews, 2022 - Elsevier
Extracellular vesicles (EVs), including microparticles and exosomes, have emerged as
potential tools for tumor targeting delivery during the past years. Recently, mass of strategies …
potential tools for tumor targeting delivery during the past years. Recently, mass of strategies …
Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications
Macrophages are key players in many physiological scenarios including tissue
homeostasis. In response to injury, typically the balance between macrophage sub …
homeostasis. In response to injury, typically the balance between macrophage sub …
Nanoparticle‐laden macrophages for tumor‐tropic drug delivery
Macrophages hold great potential in cancer drug delivery because they can sense
chemotactic cues and home to tumors with high efficiency. However, it remains a challenge …
chemotactic cues and home to tumors with high efficiency. However, it remains a challenge …
Pancreatic cancer cell exosome-mediated macrophage reprogramming and the role of microRNAs 155 and 125b2 transfection using nanoparticle delivery systems
Exosomes are nano-sized endosome-derived small intraluminal vesicles, which are
important facilitators of intercellular communication by transporting contents, such as protein …
important facilitators of intercellular communication by transporting contents, such as protein …