Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Smart and bioinspired systems for overcoming biological barriers and enhancing disease theranostics

X Li, Y Gao, H Li, JP Majoral, X Shi, A Pich - Progress in Materials Science, 2023 - Elsevier
Nanomedicine has emerged as a promising mean to improve theranostic efficacy and
reduce side effects. Currently, only very small percentage of injected dose reaches the solid …

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

X Wang, G Luo, K Zhang, J Cao, C Huang, T Jiang… - Cancer research, 2018 - AACR
Exosomes are emerging as important mediators of the cross-talk between tumor cells and
the microenvironment. However, the mechanisms by which exosomes modulate tumor …

Nanoparticles targeting macrophages as potential clinical therapeutic agents against cancer and inflammation

G Hu, M Guo, J Xu, F Wu, J Fan, Q Huang… - Frontiers in …, 2019 - frontiersin.org
With the development of nanotechnology, significant progress has been made in the design,
and manufacture of nanoparticles (NPs) for use in clinical treatments. Recent increases in …

Control of macrophage metabolism and activation by mTOR and Akt signaling

AJ Covarrubias, HI Aksoylar, T Horng - Seminars in immunology, 2015 - Elsevier
Macrophages are pleiotropic cells that assume a variety of functions depending on their
tissue of residence and tissue state. They maintain homeostasis as well as coordinate …

Combating bacterial infections with host defense peptides: Shifting focus from bacteria to host immunity

N Gao, J Wang, C Fang, P Bai, Y Sun, W Wu… - Drug Resistance …, 2024 - Elsevier
The increasing prevalence of multidrug-resistant bacterial infections necessitates the
exploration of novel paradigms for anti-infective therapy. Antimicrobial peptides (AMPs), also …

Extracellular vesicles for improved tumor accumulation and penetration

N Bie, T Yong, Z Wei, L Gan, X Yang - Advanced drug delivery reviews, 2022 - Elsevier
Extracellular vesicles (EVs), including microparticles and exosomes, have emerged as
potential tools for tumor targeting delivery during the past years. Recently, mass of strategies …

Delivery strategies to control inflammatory response: Modulating M1–M2 polarization in tissue engineering applications

MM Alvarez, JC Liu, G Trujillo-de Santiago… - Journal of Controlled …, 2016 - Elsevier
Macrophages are key players in many physiological scenarios including tissue
homeostasis. In response to injury, typically the balance between macrophage sub …

Nanoparticle‐laden macrophages for tumor‐tropic drug delivery

W Zhang, M Wang, W Tang, R Wen, S Zhou… - Advanced …, 2018 - Wiley Online Library
Macrophages hold great potential in cancer drug delivery because they can sense
chemotactic cues and home to tumors with high efficiency. However, it remains a challenge …

Pancreatic cancer cell exosome-mediated macrophage reprogramming and the role of microRNAs 155 and 125b2 transfection using nanoparticle delivery systems

MJ Su, H Aldawsari, M Amiji - Scientific reports, 2016 - nature.com
Exosomes are nano-sized endosome-derived small intraluminal vesicles, which are
important facilitators of intercellular communication by transporting contents, such as protein …