The gateway reflex regulates tissue-specific autoimmune diseases

Y Tanaka, I Ohki, K Murakami, S Ozawa… - Inflammation and …, 2024 - Springer
The dynamic interaction and movement of substances and cells between the central
nervous system (CNS) and peripheral organs are meticulously controlled by a specialized …

Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier

Y Arima, M Harada, D Kamimura, JH Park, F Kawano… - Cell, 2012 - cell.com
Although it is believed that neural activation can affect immune responses, very little is
known about the neuroimmune interactions involved, especially the regulators of immune …

Neurophysiological changes in simulated microgravity: An animal model

CM Nday, C Frantzidis, G Jackson, P Bamidis… - Neurology …, 2019 - journals.lww.com
Microgravity (MG) is one of the main problems that astronauts have to cope with during
space missions. Long-duration space travel can have detrimental effects on human …

A rat model of arthrofibrosis developed after anterior cruciate ligament reconstruction without rigid joint immobilization

A Kaneguchi, J Ozawa, K Minamimoto… - Connective Tissue …, 2021 - Taylor & Francis
Purpose: Complications including arthrofibrosis have been reported after anterior cruciate
ligament reconstruction (ACLR) even under accelerated rehabilitation. To overcome this, we …

Comprehensive dynamic and kinematic analysis of the rodent hindlimb during over ground walking

J Dienes, B Hicks, C Slater, KD Janson, GJ Christ… - Scientific Reports, 2022 - nature.com
The rat hindlimb is a frequently utilized pre-clinical model system to evaluate injuries and
pathologies impacting the hindlimbs. These studies have demonstrated the translational …

Multiscale computational model of Achilles tendon wound healing: Untangling the effects of repair and loading

K Chen, X Hu, SS Blemker… - PLoS computational …, 2018 - journals.plos.org
Mechanical stimulation of the healing tendon is thought to regulate scar anisotropy and
strength and is relatively easy to modulate through physical therapy. However, in vivo …

Significant mechanical interactions at physiological lengths and relative positions of rat plantar flexors

M Bernabei, JH van Dieën… - Journal of applied …, 2015 - journals.physiology.org
In situ studies involving supraphysiological muscle lengths and relative positions have
shown that connective tissue linkages connecting adjacent muscles can transmit substantial …

Analysis and modeling of rat gait biomechanical deficits in response to volumetric muscle loss injury

JA Dienes, X Hu, KD Janson, C Slater… - … in Bioengineering and …, 2019 - frontiersin.org
There is currently a substantial volume of research underway to develop more effective
approaches for the regeneration of functional muscle tissue as treatment for volumetric …

Kinematic and kinetic gait analysis to evaluate functional recovery in thoracic spinal cord injured rats

CC Diogo, LM da Costa, JE Pereira, V Filipe… - Neuroscience & …, 2019 - Elsevier
The recovery of walking function following spinal cord injury (SCI) is of major importance to
patients and clinicians. In experimental SCI studies, a rat model is widely used to assess …

Hindlimb unloading affects cortical motor maps and decreases corticospinal excitability

C Langlet, B Bastide, MH Canu - Experimental neurology, 2012 - Elsevier
A chronic reduction in neuromuscular activity through prolonged body immobilization of
humans results in muscle atrophy and weakness as well as motor tasks performance …