Correct expression of the genetic code at translation is directly correlated with tRNA identity.
This survey describes the molecular signals in tRNAs that trigger specific aminoacylations …

Bacteria contain a remarkable RNA molecule—known alternatively as SsrA RNA, tmRNA, or
10Sa RNA—that acts both as a tRNA and as an mRNA to direct the modification of proteins …

An improved dynamic programming algorithm is reported for RNA secondary structure
prediction by free energy minimization. Thermodynamic parameters for the stabilities of …

Interruption of translation in Escherichia coli can lead to the addition of an 11-residue
carboxy-terminal peptide tail to the nascent chain. This modification is mediated by SsrA …

The tmRNA system performs translational surveillance and ribosome rescue in all
eubacteria and some eukaryotic organelles. This system intervenes when ribosomes read to …

In bacteria, SsrA RNA recognizes ribosomes stalled on defective messages and acts as a
tRNA and mRNA to mediate the addition of a short peptide tag to the C‐terminus of the …

The trans-translation mechanism is a key component of multiple quality control pathways in
bacteria that ensure proteins are synthesized with high fidelity in spite of challenges such as …

SsrA RNA mediates the addition of a C‐terminal peptide tag (AANDENYAL AA) to bacterial
proteins translated from mRNAs without in‐frame stop codons. This process involves both …

Escherichia coli tmRNA functions uniquely as both tRNA and mRNA and possesses
structural elements similar to canonical tRNAs. To test whether this mimicry extends to post …

The SsrA or tmRNA quality control system relieves ribosome stalling and directs the addition
of a degradation tag to the C terminus of the nascent chain. In some instances, SsrA tagging …