Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

A pathological feature of Parkinson's disease (PD) is the progressive loss of dopaminergic
neurons and decreased dopamine (DA) content in the substantia nigra pars compacta in PD …

Develo** diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …

Parkinson disease (PD) is a neurodegenerative disorder marked by the preferential
dysfunction and death of dopaminergic neurons in the substantia nigra. The onset and …

Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

Chaperone-mediated autophagy (CMA) was the first studied process that indicated that
degradation of intracellular components by the lysosome can be selective—a concept that is …

Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …

Genetic studies have shown the association of Parkinson's disease with alleles of the major
histocompatibility complex,,. Here we show that a defined set of peptides that are derived …

Neuroinflammation is a pathological change that is involved in the progression of
Parkinson's disease. Dysfunction of chaperone-mediated autophagy (CMA) has …