[HTML][HTML] Subtypes of breast cancer

E Orrantia-Borunda, P Anchondo-Nuñez… - Breast Cancer …, 2022 - ncbi.nlm.nih.gov
Breast cancer is a genetically and clinically heterogeneous disease with multiple subtypes.
The classification of these subtypes has evolved over the years. The most common and …

[HTML][HTML] Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and future prospects

KM Yap, M Sekar, YS Wu, SH Gan, NNIM Rani… - Saudi Journal of …, 2021 - Elsevier
Breast cancer (BC) has high incidence and mortality rates, making it a major global health
issue. BC treatment has been challenging due to the presence of drug resistance and the …

Cancer metastases to bone: concepts, mechanisms, and interactions with bone osteoblasts

AB Shupp, AD Kolb, D Mukhopadhyay, KM Bussard - Cancers, 2018 - mdpi.com
The skeleton is a unique structure capable of providing support for the body. Bone
resorption and deposition are controlled in a tightly regulated balance between osteoblasts …

The breast tumor microenvironment: A key player in metastatic spread

LEL Terceiro, CA Edechi, NM Ikeogu, BE Nickel… - Cancers, 2021 - mdpi.com
Simple Summary The spread of breast cancer to distant parts of the body (metastasis) is the
major cause of death in breast cancer patients. Research has shown that apart from the …

Comparative study of lipophilic statin activity in 2D and 3D in vitro models of human breast cancer cell lines MDA-MB-231 and MCF-7

M Bytautaite, V Petrikaite - OncoTargets and therapy, 2020 - Taylor & Francis
Introduction Statins are a type of drugs that are used to lower cholesterol level in blood.
Since the early 1990s, it has been known that statins could be beneficial in cancer therapy …

Engineering breast cancer on-chip—moving toward subtype specific models

C Moccia, K Haase - Frontiers in Bioengineering and Biotechnology, 2021 - frontiersin.org
Breast cancer is the second leading cause of death among women worldwide, and while
hormone receptor positive subtypes have a clear and effective treatment strategy, other …

Contributions of thyroid hormone to cancer metastasis

SA Mousa, GV Glinsky, HY Lin, O Ashur-Fabian… - Biomedicines, 2018 - mdpi.com
Acting at a cell surface receptor on the extracellular domain of integrin αvβ3, thyroid
hormone analogues regulate downstream the expression of a large panel of genes relevant …

Bone marrow adipocytes: A link between obesity and bone cancer

MR Reagan, H Fairfield, CJ Rosen - Cancers, 2021 - mdpi.com
Simple Summary This review discusses the important newly-established roles for bone
marrow adipose tissue in cancer progression and highlights the research demonstrating …

Bone marrow adipocyte: an intimate partner with tumor cells in bone metastasis

G Luo, Y He, X Yu - Frontiers in endocrinology, 2018 - frontiersin.org
The high incidences of bone metastasis in patients with breast cancer, prostate cancer and
lung cancer still remains a puzzling issue. The “seeds and soil” hypothesis suggested that …

Breast Cancer and Bone Mineral Density in a US Cohort of Middle-Aged Women: Associations with Phosphate Toxicity

RB Brown, P Bigelow, JA Dubin - Cancers, 2023 - mdpi.com
Simple Summary Phosphate toxicity, the accumulation of toxic levels of phosphate in the
body, is associated with tumor growth and bone mineral abnormalities. Based on shared …