Understanding the function of regulatory DNA interactions in the interpretation of non-coding GWAS variants
Genome-wide association studies (GWAS) have identified a vast number of variants
associated with various complex human diseases and traits. However, most of these GWAS …
associated with various complex human diseases and traits. However, most of these GWAS …
Scalable approaches for functional analyses of whole-genome sequencing non-coding variants
Non-coding genetic variants outside of protein-coding genome regions play an important
role in genetic and epigenetic regulation. It has become increasingly important to …
role in genetic and epigenetic regulation. It has become increasingly important to …
DeepGWAS: Enhance GWAS Signals for Neuropsychiatric Disorders via Deep Neural Network
Genetic dissection of neuropsychiatric disorders can potentially reveal novel therapeutic
targets. While genome-wide association studies (GWAS) have tremendously advanced our …
targets. While genome-wide association studies (GWAS) have tremendously advanced our …
MagicalRsq: Machine-learning-based genotype imputation quality calibration
Whole-genome sequencing (WGS) is the gold standard for fully characterizing genetic
variation but is still prohibitively expensive for large samples. To reduce costs, many studies …
variation but is still prohibitively expensive for large samples. To reduce costs, many studies …
Gene Association Analysis of Quantitative Trait Based on Functional Linear Regression Model with Local Sparse Estimator
J Wang, F Zhou, C Li, N Yin, H Liu, B Zhuang, Q Huang… - Genes, 2023 - mdpi.com
Functional linear regression models have been widely used in the gene association
analysis of complex traits. These models retain all the genetic information in the data and …
analysis of complex traits. These models retain all the genetic information in the data and …
Increasing Diversity with Statistical Methods in Genetics Studies
Q Sun - 2024 - search.proquest.com
With the development of genoty** and sequencing technologies, genetics data have
become increasingly available, making genetic studies unprecedentedly flourishing …
become increasingly available, making genetic studies unprecedentedly flourishing …
RetroFun‐RVS: A Retrospective Family‐Based Framework for Rare Variant Analysis Incorporating Functional Annotations
ABSTRACT A large proportion of genetic variations involved in complex diseases are rare
and located within noncoding regions, making the interpretation of underlying biological …
and located within noncoding regions, making the interpretation of underlying biological …