Brain-derived neurotrophic factor (BDNF) is a neuropeptide that plays numerous important
roles in synaptic development and plasticity. While its importance in fundamental physiology …

Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Post-stroke depression (PSD) is one of common and serious sequelae of stroke.
Approximately, one in three stroke survivors suffered from depression after stroke. It heavily …

Using behavioral, pharmacological, and molecular methods, lots of studies reveal that
depression is closely related to the abnormal neural plasticity processes occurring in the …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

Brain derived neurotrophic factor (BDNF) has multiple biological functions which are
mediated by the activation of two receptors, tropomyosin receptor kinase B (TrkB) receptor …

Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

The pathophysiology and treatment of depression have been the focus of intense research
and while there is much that remains unknown, modern neurobiological approaches are …

Ketamine has been found to have rapid and potent antidepressant activity. However, despite
the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor …