In this review, we attempt to give a concise overview of recent progress made in mechanistic
understanding of protein aggregation, particulate formation and protein solution rheology …

Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a
significant part of the early colloid literature was focused on protein solutions. However, it …

Detection of single analyte molecules without the use of any label would improve the
sensitivity of current biosensors by orders of magnitude to the ultimate graininess of …

We develop a detailed description of protein translational and rotational diffusion in
concentrated solution on the basis of all-atom molecular dynamics simulations in explicit …

The effects of crowding in biological environments on biomolecular structure, dynamics, and
function remain not well understood. Computer simulations of atomistic models of …

The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …

For a long time, the effect of a crowded cellular environment on protein dynamics has been
largely ignored. Recent experiments indicate that proteins diffuse more slowly in a living cell …

Highlights•Colloidal approaches to understand concentrated globular protein
solutions.•Structure-viscosity relationship for concentrated monoclonal antibody …

The mechanical properties of the cell nucleus are increasingly recognized as critical in many
biological processes. The deformability of the nucleus determines the ability of immune and …

Tuning of protein surface charge is a fundamental mechanism in biological systems. Protein
charge is regulated in a physiological context by pH and interaction with counterions. We …