Background Posttraumatic stress disorder, an area of large unmet medical needs, is
characterized by persistence of fear memories and maladaptive stress responses. In …

Brain sex differences are established developmentally and generate enduring changes in
circuitry and behavior. Steroid-mediated masculinization of the rat amygdala during …

Simple Summary Cannabis is widely used by patients with cancer to help with cancer
symptoms and treatment side effects. Though cannabis has immunomodulatory effects, and …

Post-traumatic stress disorder (PTSD) is a common, debilitating condition with limited
treatment options. Extinction of fear memories through prolonged exposure therapy, the …

Endocannabinoids (ECs) are endogenous lipid-based retrograde neurotransmitters that
bind to cannabinoid receptors [cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 …

Background and Purpose Women are twice as likely as men to develop post‐traumatic
stress disorder (PTSD) making the search for biological mechanisms underlying these …

Exposure to a traumatic event may result in the development of post-traumatic stress
disorder (PTSD). Endocannabinoids are crucial modulators of the stress response, interfere …

Increased anandamide (AEA) signaling through inhibition of its catabolic enzyme fatty acid
amide hydrolase (FAAH) in the basolateral complex of amygdala (BLA) is thought to buffer …

Early-life inflammation has been shown to exert profound effects on brain development and
behavior, including altered emotional behavior, stress responsivity and neurochemical …

Cannabis use during pregnancy has increased over the past few decades, with recent data
indicating that, in youth and young adults especially, up to 22% of people report using …