Molecular mechanisms of transgenerational epigenetic inheritance

MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …

Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics

L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms

R Yehuda, A Lehrner - World psychiatry, 2018 - Wiley Online Library
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …

Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment

E Stener-Victorin, Q Deng - Nature Reviews Endocrinology, 2021 - nature.com
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …

Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development

A Lismer, S Kimmins - Nature communications, 2023 - nature.com
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Intergenerational and transgenerational epigenetic inheritance in animals

MF Perez, B Lehner - Nature cell biology, 2019 - nature.com
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

The molecular hallmarks of epigenetic control

CD Allis, T Jenuwein - Nature Reviews Genetics, 2016 - nature.com
Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …

Cannabis and synaptic reprogramming of the develo** brain

A Bara, JMN Ferland, G Rompala, H Szutorisz… - Nature Reviews …, 2021 - nature.com
Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder

Q Chen, M Yan, Z Cao, X Li, Y Zhang, J Shi, G Feng… - Science, 2016 - science.org
Increasing evidence indicates that metabolic disorders in offspring can result from the
father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat …

Functions and mechanisms of epigenetic inheritance in animals

K Skvortsova, N Iovino, O Bogdanović - Nature reviews Molecular cell …, 2018 - nature.com
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …