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Molecular mechanisms of transgenerational epigenetic inheritance
MH Fitz-James, G Cavalli - Nature Reviews Genetics, 2022 - nature.com
Increasing evidence indicates that non-DNA sequence-based epigenetic information can be
inherited across several generations in organisms ranging from yeast to plants to humans …
inherited across several generations in organisms ranging from yeast to plants to humans …
Gene–environment interactions in Alzheimer disease: the emerging role of epigenetics
L Migliore, F Coppedè - Nature Reviews Neurology, 2022 - nature.com
With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …
Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms
This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …
Epigenetic inheritance of polycystic ovary syndrome—challenges and opportunities for treatment
Polycystic ovary syndrome (PCOS) is the main cause of female infertility worldwide and is
associated with a substantially increased lifetime risk of comorbidities, including type 2 …
associated with a substantially increased lifetime risk of comorbidities, including type 2 …
Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
Intergenerational and transgenerational epigenetic inheritance in animals
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
The molecular hallmarks of epigenetic control
CD Allis, T Jenuwein - Nature Reviews Genetics, 2016 - nature.com
Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …
associated mechanisms that alter chromatin in response to physiological or pathological …
Cannabis and synaptic reprogramming of the develo** brain
Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …
benefits of cannabis with increased acceptance of use. This has unintended …
Sperm tsRNAs contribute to intergenerational inheritance of an acquired metabolic disorder
Increasing evidence indicates that metabolic disorders in offspring can result from the
father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat …
father's diet, but the mechanism remains unclear. In a paternal mouse model given a high-fat …
Functions and mechanisms of epigenetic inheritance in animals
The idea that epigenetic determinants such as DNA methylation, histone modifications or
RNA can be passed to the next generation through meiotic products (gametes) is long …
RNA can be passed to the next generation through meiotic products (gametes) is long …