Complex cellular events commonly depend on the activity of molecular “machines” that
efficiently couple enzymatic and regulatory functions within a multiprotein assembly. An …

FtsH is a cytoplasmic membrane protein that has N-terminally located transmembrane
segments and a main cytosolic region consisting of AAA-ATPase and Zn2+-metalloprotease …

The AAA+ ATPases are enzymes containing a P-loop NTPase domain, and function as
molecular chaperones, ATPase subunits of proteases, helicases or nucleic-acid-stimulated …

Type III protein secretion systems are essential virulence factors of many bacteria
pathogenic to humans, animals and plants. These systems mediate the transfer of bacterial …

Myxobacteria are single-celled, but social, eubacterial predators. Upon starvation they build
multicellular fruiting bodies using a developmental program that progressively changes the …

Accumulation of neurotoxic amyloid-β is a major hallmark of Alzheimer's disease. Formation
of amyloid-β is catalysed by γ-secretase, a protease with numerous substrates,. Little is …

Nature is home to a variety of microorganisms that create materials under environmentally
friendly conditions. While this offers an attractive approach for sustainable manufacturing …

Autosomal dominant spinocerebellar ataxias (SCAs) are genetically heterogeneous
neurological disorders characterized by cerebellar dysfunction mostly due to Purkinje cell …

Human misfolding diseases result from the failure of proteins to reach their active state or
from the accumulation of aberrantly folded proteins. The mechanisms by which molecular …

Clp proteolytic complexes consisting of a proteolytic core flanked by Clp ATPases are widely
conserved in bacteria, and their biological roles have received considerable interest. In …