Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …

Many clinically used drugs are derived from or inspired by bacterial natural products that
often are produced through nonribosomal peptide synthetases (NRPSs), megasynthetases …

Corals are associated with a variety of bacteria, which occur in the surface mucus layer,
gastrovascular cavity, skeleton, and tissues. Some tissue-associated bacteria form clusters …

The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …

Covering: up to 2018 β-Lactones are strained rings that are useful organic synthons and
pharmaceutical warheads. Over 30 core scaffolds of β-lactone natural products have been …

Burkholderia bacteria are multifaceted organisms that are ecologically and metabolically
diverse. The Burkholderia genus has gained prominence because it includes human …

Recombination-mediated genetic engineering, also known as recombineering, is the
genomic incorporation of homologous single-stranded or double-stranded DNA into …

Abstract Background In octocorals (Cnidaria Octocorallia), the functional relationship
between host health and its symbiotic consortium has yet to be determined. Here, we …

Endophytes represent microorganisms residing within plant tissues without typically causing
any adverse effect to the plants for considerable part of their life cycle and are primarily …