Cardiac diseases form the lion's share of the global disease burden, owing to the paradigm
shift to non-infectious diseases from infectious ones. The prevalence of CVDs has nearly …

Cardiac fibroblasts deposit and maintain extracellular matrix during organogenesis and
under physiological conditions. In the adult heart, activated cardiac fibroblasts also …

Cardiac fibrosis, characterized by excessive deposition of extracellular matrix (ECM)
proteins in the myocardium, distorts the architecture of the myocardium, facilitates the …

Atrial fibrillation (AF) is associated with structural, electrical, and contractile remodeling of
the atria. Development and progression of atrial fibrosis is the hallmark of structural …

Galectin-3 is a β-galactoside-binding lectin which is important in numerous biological
activities in various organs, including cell proliferation, apoptotic regulation, inflammation …

Myocardial fibrosis is an important part of cardiac remodeling that leads to heart failure and
death. Myocardial fibrosis results from increased myofibroblast activity and excessive …

Galectin-3 is a beta-galactoside-binding mammalian lectin and part of the 15 member
galectin family that are evolutionarily highly conserved. It is the only chimeric protein with a …

Objective—Aldosterone (Aldo) is involved in arterial stiffness and heart failure, but the
mechanisms have remained unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin …

The fundamental mechanisms governing the perpetuation of atrial fibrillation (AF), the most
common arrhythmia seen in clinical practice, are poorly understood, which explains in part …

Fibrotic diseases occur in a variety of organs and lead to continuous organ injury, function
decline, and even failure. Currently effective treatment options are limited. Galectin-3 (Gal-3) …