Genomes of all living organisms are constantly threatened by endogenous and exogenous
agents that challenge the chemical integrity of DNA. Most bacteria have evolved a …

Although homologous recombination and DNA repair phenomena in bacteria were initially
extensively studied without regard to any relationship between the two, it is now appreciated …

When duplex DNA is altered in almost any way (replicated, recombined, or repaired), single
strands of DNA are usually intermediates, and single-stranded DNA binding (SSB) proteins …

▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to
humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the …

DNA polymerase III holoenzyme contains two DNA polymerases embedded in a particle
with 9 other subunits. This multi subunit DNA polymerase is the Escherichia coli …

The interaction between DNA polymerases and sliding clamp proteins confers processivity
in DNA synthesis. This interaction is critical for most DNA replication machines from viruses …

High accuracy (fidelity) of DNA replication is important for cells to preserve the genetic
identity and to prevent the accumulation of deleterious mutations. The error rate during DNA …

The SSB protein of Escherichia coli functions to bind single-stranded DNA wherever it
occurs during DNA metabolism. Depending upon conditions, SSB occurs in several different …

The β and proliferating cell nuclear antigen (PCNA) sliding clamps were first identified as
components of their respective replicases, and thus were assigned a role in chromosome …

Archaeal organisms are currently recognized as very exciting and useful experimental
materials. A major challenge to molecular biologists studying the biology of Archaea is their …