Mechanisms in endocrinology: Heart failure and thyroid dysfunction

B Biondi - European journal of endocrinology, 2012 - academic.oup.com
Context Heart failure (HF) is a major cause of morbidity and mortality in Europe and in the
United States. The aim of this review article was to assess the results of the prospective …

Thyroid replacement therapy and heart failure

AM Gerdes, G Iervasi - Circulation, 2010 - Am Heart Assoc
Heart failure (HF) is a major public health and economic problem in Western countries and
is one of the most common causes of hospitalization and death. Coronary artery disease is …

Cardiac hypertrophy and thyroid hormone signaling

W Dillmann - Heart failure reviews, 2010 - Springer
Thyroid hormone exerts a large number of influences on the cardiovascular system.
Increased thyroid hormone action increases the force and speed of systolic contraction and …

Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways

A Kenessey, K Ojamaa - Journal of Biological Chemistry, 2006 - ASBMB
Thyroid hormones affect cardiac growth and phenotype; however, the mechanisms by which
the hormones induce cardiomyocyte hypertrophy remain uncharacterized. Tri-iodo-l …

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction

YD Tang, JA Kuzman, S Said, BE Anderson, X Wang… - Circulation, 2005 - Am Heart Assoc
Background—Although thyroid dysfunction has been linked to heart failure, it is not clear
whether hypothyroidism alone can cause heart failure. Methods and Results …

The role of thyroid hormones in heart failure

C Vale, JS Neves, M von Hafe… - … drugs and therapy, 2019 - Springer
Cardiovascular diseases are the leading cause of death worldwide. Heart failure is the
terminal manifestation of cardiovascular diseases, and its morbidity and mortality remain …

The role of thyroid hormone in the pathophysiology of heart failure: clinical evidence

E Galli, A **itore, G Iervasi - Heart failure reviews, 2010 - Springer
Thyroid hormone (TH) has a fundamental role in cardiovascular homeostasis in both
physiological and pathological conditions, influencing cardiac contractility, heart rate (HR) …

Cobalt cardiomyopathy: a critical reappraisal in light of a recent resurgence

M Packer - Circulation: Heart Failure, 2016 - Am Heart Assoc
Cobalt can cause a distinctive, rapidly progressive and reversible depression of cardiac
systolic function, which is readily distinguished from other causes of cardiomyopathy …

Activation of host tissue trophic factors through JAK-STAT3 signaling: a mechanism of mesenchymal stem cell-mediated cardiac repair

A Shabbir, D Zisa, H Lin, M Mastri… - American Journal …, 2010 - journals.physiology.org
We recently demonstrated a cardiac therapeutic regimen based on injection of bone marrow
mesenchymal stem cells (MSCs) into the skeletal muscle. Although the injected MSCs were …

Serum thyroid hormone levels may not accurately reflect thyroid tissue levels and cardiac function in mild hypothyroidism

Y Liu, RA Redetzke, S Said… - American Journal …, 2008 - journals.physiology.org
The link between thyroid dysfunction and cardiovascular diseases has been recognized for
more than 100 years. Although overt hypothyroidism leads to impaired cardiac function and …