It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer
cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better …

Maintaining systemic homeostasis requires the coordination of different organs and tissues
in the body. Our bodies rely on complex inter-organ communications to adapt to …

Uncoupling protein 2 (UCP2) uncouples respiration from oxidative phosphorylation and may
contribute to obesity through effects on energy metabolism. Because basal metabolic rate is …

The liver is an important site of host-microbe interaction. Although hepatocytes have been
reported to be responsive to lipopolysaccharide (LPS), the global gene expression changes …

Background: Elevations in liver function tests have been reported in patients receiving total
parenteral nutrition (TPN). The clinical aspects of end-stage liver disease (ESLD) associated …

Drug-induced liver injury induced by already approved substances is a major threat to
human patients, potentially resulting in drug withdrawal and substantial loss of financial …

Abstract Effects on the liver C3A cell line treated with a panel of engineered nanomaterials
(NMs) consisting of two zinc oxide particles (ZnO; coated 100 nm and uncoated 130 nm) …

Tumor necrosis factor (TNF) signaling through TNF receptor 1 (TNFR1) with downstream
participation of nuclear factor κB (NFκB), interleukin 6 (IL-6), and signal transducers and …

Severe acute pancreatitis (AP) is associated with both the local (pancreatic) release of
cytokines and an elevation in their systemic plasma concentrations. This may lead to organ …

Objective: Nitric oxide has been proposed as a mediator of hyperdynamic circulation in
cirrhosis. Endotoxin and cytokines induce the synthesis of nitric oxide. The aim of this study …