Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …

Cancer stem cells (CSC) are a distinct subpopulation within a tumor. They are able to self-
renew and differentiate and possess a high capability to repair DNA damage, exhibit low …

Radiomics applies machine learning algorithms to quantitative imaging data to characterise
the tumour phenotype and predict clinical outcome. For the development of radiomics risk …

Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing
technology represents a significant breakthrough in personalized immunotherapy for human …

Current algorithms for the clinical management of patients with squamous cell carcinoma of
the head and neck (HNSCC) are based on a stage-dependent strategy where all patients at …

Head and neck cancer is a common and aggressive malignancy with a high morbidity and
mortality profile. Although the large majority of cases resemble head and neck squamous …

Background Hypoxia is a well recognised parameter of tumour resistance to radiotherapy, a
number of anticancer drugs and potentially immunotherapy. In a previously published …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed
cancer worldwide. Despite advances in the treatment management, locally advanced …

Cancer stem cells (CSCs) are self-renewing and slow-multiplying micro subpopulations in
tumour microenvironments. CSCs contribute to cancer's resistance to radiation (including …

Background Despite multimodal therapy, 5-year overall survival for locally advanced head
and neck squamous cell carcinoma (HNSCC) is about 50%. We assessed the addition of …