Motor and non-motor circuit disturbances in early Parkinson disease: which happens first?

J Blesa, G Foffani, B Dehay, E Bezard… - Nature Reviews …, 2022 - nature.com
For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

N Itoh, Y Itoh, A Tassoni, E Ren, M Kaito… - Proceedings of the …, 2018 - pnas.org
Changes in gene expression that occur across the central nervous system (CNS) during
neurological diseases do not address the heterogeneity of cell types from one CNS region to …

[HTML][HTML] A comprehensive review of the advances in neuromyelitis optica spectrum disorder

P Siriratnam, S Huda, H Butzkueven, A Van der Walt… - Autoimmunity …, 2023 - Elsevier
Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing neuroinflammatory
autoimmune astrocytopathy, with a predilection for the optic nerves and spinal cord. Most …

Cognitive impairment in multiple sclerosis–a review of current knowledge and recent research

T Grzegorski, J Losy - Reviews in the Neurosciences, 2017 - degruyter.com
Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system that is
characterised by inflammatory damage to the myelin sheath. Though often neglected …

Cognitive dysfunctions and assessments in multiple sclerosis

C Oreja-Guevara, T Ayuso Blanco… - Frontiers in …, 2019 - frontiersin.org
Cognitive impairment has been reported at all phases and all subtypes of multiple sclerosis.
It remains a major cause of neurological disability in young and middle-aged adults suffering …

The effects of SARS-CoV-2 infection on the cognitive functioning of patients with pre-existing dementia

S Dubey, S Das, R Ghosh, MJ Dubey… - Journal of …, 2023 - journals.sagepub.com
Background: Cognitive postscripts of COVID-19, codenamed as 'cognitive COVID'or 'brain
fog,'characterized by multidomain cognitive impairments, are now being reckoned as the …

Predictors of multiple sclerosis progression: A systematic review of conventional magnetic resonance imaging studies

NB Lomer, KAA Asalemi, A Saberi, K Sarlak - Plos one, 2024 - journals.plos.org
Introduction Multiple Sclerosis (MS) is a chronic neurodegenerative disorder that affects the
central nervous system (CNS) and results in progressive clinical disability and cognitive …

Interleukin-17 affects synaptic plasticity and cognition in an experimental model of multiple sclerosis

M Di Filippo, A Mancini, L Bellingacci, L Gaetani… - Cell reports, 2021 - cell.com
Cognitive impairment (CI) is a disabling concomitant of multiple sclerosis (MS) with a
complex and controversial pathogenesis. The cytokine interleukin-17A (IL-17A) is involved …

Synaptic elimination in neurological disorders

PL Cardozo, IBQ de Lima, EMA Maciel… - Current …, 2019 - benthamdirect.com
Synapses are well known as the main structures responsible for transmitting information
through the release and recognition of neurotransmitters by pre-and post-synaptic neurons …