Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications

Q Tuo, S Zhang, P Lei - Medicinal research reviews, 2022 - Wiley Online Library
Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Curcumin, the active substance of turmeric: its effects on health and ways to improve its bioavailability

ME Abd El‐Hack, MT El‐Saadony… - Journal of the …, 2021 - Wiley Online Library
Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as
an aromatic stimulant, a food preservative, and coloring material. The commonly used …

Cerium oxide nanoparticles with antioxidative neurorestoration for ischemic stroke

X Li, Z Han, T Wang, C Ma, H Li, H Lei, Y Yang… - Biomaterials, 2022 - Elsevier
Oxidative stress and mitochondrial damage are the main mechanisms of ischemia-
reperfusion injury in ischemic stroke. Herein, cerium oxide nanoparticles with powerful free …

Advances in acute ischemic stroke therapy

Y **ong, AK Wakhloo, M Fisher - Circulation research, 2022 - Am Heart Assoc
The treatment of acute ischemic stroke continues to advance. The mainstay of treatment
remains intravenous thrombolysis with alteplase. Recent studies demonstrated that later …

Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells

D Belov Kirdajova, J Kriska, J Tureckova… - Frontiers in cellular …, 2020 - frontiersin.org
A plethora of neurological disorders shares a final common deadly pathway known as
excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and …

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro-and antiapoptotic proteins

AB Uzdensky - Apoptosis, 2019 - Springer
Ischemic stroke is the leading cause of human disability and mortality in the world. The main
problem in stroke therapy is the search of efficient neuroprotector capable to rescue neurons …

Clinically ineffective reperfusion after endovascular therapy in acute ischemic stroke

X Nie, X Leng, Z Miao, M Fisher, L Liu - Stroke, 2023 - Am Heart Assoc
Endovascular treatment is a highly effective therapy for acute ischemic stroke due to large
vessel occlusion. However, in clinical practice, nearly half of the patients do not have …

The impact of estrogen and estrogen-like molecules in neurogenesis and neurodegeneration: beneficial or harmful?

FA Bustamante-Barrientos… - Frontiers in Cellular …, 2021 - frontiersin.org
Estrogens and estrogen-like molecules can modify the biology of several cell types.
Estrogen receptors alpha (ERα) and beta (ERβ) belong to the so-called classical family of …

Role of calcium signaling pathway‐related gene regulatory networks in ischemic stroke based on multiple WGCNA and single‐cell analysis

W Lin, Y Wang, Y Chen, Q Wang… - Oxidative medicine and …, 2021 - Wiley Online Library
Background. This study is aimed at investigating the changes in relevant pathways and the
differential expression of related gene expression after ischemic stroke (IS) at the single‐cell …

Sodium butyrate attenuated neuronal apoptosis via GPR41/Gβγ/PI3K/Akt pathway after MCAO in rats

Z Zhou, N Xu, N Matei, DW McBride… - Journal of Cerebral …, 2021 - journals.sagepub.com
Sodium butyrate, a short-chain fatty acid, is predominantly produced by gut microbiota
fermentation of dietary fiber and serves as an important neuromodulator in the central …