As the pulsatile cardiac blood flow drives the heart valve leaflets to open and close, the flow
in the vicinity of the valve resembles a pulsed jet through a nonaxisymmetric orifice with a …

The aortic valve (AV) experiences a complex mechanical environment, which includes
tension, flexure, pressure, and shear stress forces due to blood flow during each cardiac …

Objective—Hemodynamics has been associated with aortic valve (AV) inflammation, but the
underlying mechanisms are not well understood. Here we tested the hypothesis that altered …

While computational fluid dynamics (CFD) is commonly used for medical device
development, its usefulness for demonstrating device safety has not been proven. Reliable …

Background Computational modeling of cardiovascular flow is a growing and useful field,
but such simulations usually require the researcher to guess the flow's inlet and outlet …

A model for platelet activation based on the theory of damage, incorporating cumulative
effects of stress history and past damage (senescence) was applied to a three‐dimensional …

Bileaflet mechanical heart valves (BMHV) are widely used to replace diseased heart valves.
Implantation of BMHV, however, has been linked with major complications, which are …

We present comprehensive particle image velocimetry measurements and direct numerical
simulation (DNS) of physiological, pulsatile flow through a clinical quality bileaflet …

Computational fluid dynamics (CFD) modeling of blood flow plays an important role in better
understanding various medical conditions, designing more effective drug delivery systems …

Abstract Systolic Anterior Motion (SAM) of the mitral valve–often associated with
Hypertrophic Obstructive Cardiomyopathy (HOCM)–is a cardiac pathology in which a …