SNP discovery using a pangenome: has the single reference approach become obsolete?
Increasing evidence suggests that a single individual is insufficient to capture the genetic
diversity within a species due to gene presence absence variation. In order to understand …
diversity within a species due to gene presence absence variation. In order to understand …
Efficiency and power in genetic association studies
We investigated selection and analysis of tag SNPs for genome-wide association studies by
specifically examining the relationship between investment in genoty** and statistical …
specifically examining the relationship between investment in genoty** and statistical …
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder,
starting in early childhood and persisting into adulthood in the majority of cases. Family and …
starting in early childhood and persisting into adulthood in the majority of cases. Family and …
Hierarchical clustering to find representative operating periods for capacity-expansion modeling
Power system capacity-expansion models are typically intractable if every operating period
is represented. This issue is normally overcome by using a subset of representative …
is represented. This issue is normally overcome by using a subset of representative …
Hierarchical clustering with prototypes via minimax linkage
Agglomerative hierarchical clustering is a popular class of methods for understanding the
structure of a dataset. The nature of the clustering depends on the choice of linkage—that is …
structure of a dataset. The nature of the clustering depends on the choice of linkage—that is …
Multi-level aircraft feature representation and selection for aviation environmental impact analysis
A wholesome understanding of aviation's environmental impacts is indispensable to the
realization of a sustainable future of aviation. An accurate assessment of aircraft features …
realization of a sustainable future of aviation. An accurate assessment of aircraft features …
ELKI: A large open-source library for data analysis-ELKI Release 0.7. 5" Heidelberg"
This paper documents the release of the ELKI data mining framework, version 0.7. 5. ELKI is
an open source (AGPLv3) data mining software written in Java. The focus of ELKI is …
an open source (AGPLv3) data mining software written in Java. The focus of ELKI is …
Statistical advances and challenges for analyzing correlated high dimensional SNP data in genomic study for complex diseases
Y Liang, A Kelemen - 2008 - projecteuclid.org
Recent advances of information technology in biomedical sciences and other applied areas
have created numerous large diverse data sets with a high dimensional feature space …
have created numerous large diverse data sets with a high dimensional feature space …
[HTML][HTML] A genetic algorithm–support vector machine method with parameter optimization for selecting the tag SNPs
SNPs (Single Nucleotide Polymorphisms) include millions of changes in human genome,
and therefore, are promising tools for disease-gene association studies. However, this kind …
and therefore, are promising tools for disease-gene association studies. However, this kind …
Establishing multiple omics baselines for three Southeast Asian populations in the Singapore Integrative Omics Study
Abstract The Singapore Integrative Omics Study provides valuable insights on establishing
population reference measurement in 364 Chinese, Malay, and Indian individuals. These …
population reference measurement in 364 Chinese, Malay, and Indian individuals. These …