Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …

The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …

In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

The transition of RNA polymerase II (Pol II) from initiation to productive elongation is a
central, regulated step in metazoan gene expression. At many genes, Pol II pauses stably in …

Initiation and promoter-proximal pausing are key regulatory steps of RNA Polymerase II (Pol
II) transcription. To study the in vivo dynamics of endogenous Pol II during these steps, we …

The precise regulation of RNA Polymerase II (Pol II) transcription after genotoxic stress is
crucial for proper execution of the DNA damage-induced stress response. While stalling of …

It is currently assumed that 3D chromosomal organization plays a central role in
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …

The concept of early termination as an important means of transcriptional control has long
been established. Even so, its role in metazoan gene expression is underappreciated …

RNA polymerase II (Pol II) transcribes hundreds of thousands of transcription units–a
reaction always brought to a close by its termination. Because Pol II transcribes multiple …

Promoter-proximal pausing by RNA Pol II is a rate-determining step in gene transcription
that is hypothesized to be a prominent point at which regulatory factors act. The pausing …