[HTML][HTML] Osteoarthritis phenotypes and novel therapeutic targets

WE Van Spil, O Kubassova, M Boesen… - Biochemical …, 2019‏ - Elsevier
The success of disease-modifying osteoarthritis drug (DMOAD) development is still elusive.
While there have been successes in preclinical and early clinical studies, phase 3 clinical …

What drives osteoarthritis?—synovial versus subchondral bone pathology

T Hügle, J Geurts - Rheumatology, 2017‏ - academic.oup.com
Subchondral bone and the synovium play an important role in the initiation and progression
of OA. MRI often permits an early detection of synovial hypertrophy and bone marrow …

PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis

W Jiang, Y **, S Zhang, Y Ding, K Huo, J Yang… - Bone research, 2022‏ - nature.com
Abstract Prostaglandin E2 (PGE2), a major cyclooxygenase-2 (COX-2) product, is highly
secreted by the osteoblast lineage in the subchondral bone tissue of osteoarthritis (OA) …

Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis

D McGonagle, TG Baboolal, E Jones - Nature Reviews Rheumatology, 2017‏ - nature.com
The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in
the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone …

Osteoarthritis pathogenesis–a complex process that involves the entire joint

GS Man, G Mologhianu - Journal of medicine and life, 2014‏ - pmc.ncbi.nlm.nih.gov
Osteoarthritis is the most common joint disorder and a major cause of disability with a major
socio-economic impact. In these circumstances is very important to understand its …

The bone–cartilage unit in osteoarthritis

RJ Lories, FP Luyten - Nature Reviews Rheumatology, 2011‏ - nature.com
Osteoarthritis (OA) refers to a group of mechanically-induced joint disorders to which both
genetic and acquired factors contribute. Current pathophysiological concepts focus on OA …

Diagnosis of osteoarthritis: imaging

HJ Braun, GE Gold - Bone, 2012‏ - Elsevier
Osteoarthritis (OA) is a chronic, debilitating joint disease characterized by degenerative
changes to the bones, cartilage, menisci, ligaments, and synovial tissue. Imaging modalities …

Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation

Z Cui, H Wu, Y **ao, T Xu, J Jia, H Lin, R Lin, K Chen… - Bone research, 2022‏ - nature.com
The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA)
remain unknown. No pharmacological intervention can currently prevent the progression of …

Osteochondral lesions of the knee: differentiating the most common entities at MRI

T Gorbachova, Y Melenevsky, M Cohen… - Radiographics, 2018‏ - pubs.rsna.org
Several pathologic conditions may manifest as an osteochondral lesion of the knee that
consists of a localized abnormality involving subchondral marrow, subchondral bone, and …