Granulomas, organized aggregates of immune cells which form in response to
Mycobacterium tuberculosis (Mtb), are characteristic but not exclusive of tuberculosis (TB) …

The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal
strategy in the pursuit of refined treatment methodologies for pulmonary disorders. This …

Rationale: Chest computed tomography (CT) scans are essential to diagnose and monitor
bronchiectasis (BE). To date, few quantitative data are available about the nature and extent …

Lung parenchymal hypoxia has emerged as a cardinal feature of idiopathic pulmonary
fibrosis (IPF). Hypoxia promotes cancer cell invasion and metastasis through signaling that …

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which
repetitive epithelial injury and incomplete alveolar repair result in accumulation of profibrotic …

Rationale: Non–cystic fibrosis bronchiectasis (NCFB) may originate in bronchiolar regions of
the lung. Accordingly, there is a need to characterize the morphology and molecular …

Environmental exposures increase the risk for severe lung disease, but specific drivers of
persistent epithelial injury and immune dysfunction remain unclear. Here, we identify a …

Background The airway epithelium (AE) fulfils multiple functions to maintain pulmonary
homeostasis, among which ensuring adequate barrier function, cell differentiation and …

Background Immune checkpoint inhibitors (ICI) plus chemotherapy is the preferred first-line
treatment for advanced driver-negative lung adenocarcinoma (LUAD). The DNA damage …

Background: The biological mechanisms leading some tobacco-exposed individuals to
develop early-stage chronic obstructive pulmonary disease (COPD) are poorly understood …